Formulator’s Take: Building the Ultimate Fat Loss Stack
Designing a fat loss system that actually works, without relying on excessive stimulants, is both an art and a science. As a brand that innovates continuously, we at Unmatched® are looking for more than just temporary water loss or jittery energy.
We want thermogenesis, appetite regulation, fat oxidation, muscle preservation, and metabolic resilience -- All working synergistically together to create an environment that encourages efficient fat loss in the most healthful way possible—one that complements a sound nutrition and training regimen. That’s why this stack doesn’t just burn fat—it shifts your body into an energy burning machine!
Here's a breakdown of the most advanced ingredients that form the backbone of the Ultimate Fat Loss Stack and why each one is unique in its benefits for fat loss.
Sinetrol® – The Citrus Powerhouse
Standardized to polyphenols from orange, grapefruit, and guarana, Sinetrol® has been clinically shown to promote fat breakdown (lipolysis) through the increase in cAMP activity and reducing phosphodiesterase (PDE), which helps maintain elevated levels of cAMP. Cyclic AMP plays a crucial role in facilitating the mobilization of fat cell reserves to boost metabolism. Human studies have shown that Sinetrol® can help reduce abdominal fat and improve waist-to-hip ratios, all without overstimulation. Its ability to support thermogenesis and fat oxidation, while preserving lean mass, makes it a powerful non-stimulant addition to any comprehensive fat loss regimen.
MitoBurn® (L-BAIBA) – The Exercise Signal Amplifier
L-BAIBA is a myokine triggered by exercise—often called an “exercise mimetic.” It helps stimulate brown adipose tissue (BAT) activity and promotes the "browning" of white fat cells, leading to increased thermogenesis and calorie burning. Additionally, MitoBurn® supports improved glucose regulation and insulin sensitivity, which are key factors that are crucial for efficient fat loss. By mimicking some of the metabolic benefits of exercise, MitoBurn® serves as a unique tool for enhancing fat burning, especially when paired with a calorie-controlled diet and active lifestyle.
DNF-10® – Hunger Suppressing Peptide
DNF-10® is a patented hydrolyzed yeast protein extract derived from Saccharomyces cerevisiae, clinically studied for its ability to reduce appetite and support weight management through the boosting of satiety signals like GLP-1. Its primary mechanism is through modulation of appetite-regulating hormones such as ghrelin, which helps decrease feelings of hunger and reduce caloric intake. Human clinical studies have shown that DNF-10® can lead to significant reductions in body weight, waist circumference, and fat mass over time, as well as boosts in mood. As a non-stimulant ingredient, it pairs well with other thermogenic or metabolic enhancers, making it a valuable addition to any fat loss stack aimed at improving satiety and controlling food cravings.
Coleus forskohlii (Standardized for Forskolin) – The Fat Mobilizer
Coleus forskohlii, standardized for its active compound forskolin, is a botanical extract that works by activating the enzyme adenylate cyclase, which increases intracellular levels of cyclic AMP (cAMP), which is the second messenger that tells your body to burn fat instead of storing it. Elevated cAMP levels can be crucial for promoting the breakdown of stored fat (lipolysis) for energy and support lean body mass by enhancing overall metabolic activity. Clinical studies have shown that supplementation with Coleus forskohlii can help reduce body fat percentage, especially when combined with a healthy diet and exercise. Used properly, Forskolin is a staple and synergistic ingredient in many modern fat burning formulas due to its dual action in mobilizing fat and preserving muscle and can often be utilized in conjunction with ingredients like Sinetrol® and Paraxanthine to maintain metabolic output while in a caloric deficit.
Paraxanthine (enfinity®) – Clean Focused Energy
Paraxanthine, the primary metabolite of caffeine, has garnered popularity for its ability to offer a refined and isolated approach to enhancing overall fat loss. Unlike traditional caffeine, paraxanthine has been shown to deliver clean energy and heightened mental focus without the common negative side effects like jitters, crashes, irritability and sleeplessness, which are often experienced with traditional caffeine sources. Paraxanthine can effectively stimulate lipolysis—the breakdown of fat into usable energy—by increasing cAMP levels and enhancing thermogenesis. Additionally, paraxanthine can improve muscular endurance and support physical performance during training sessions, which translates to more effective workouts and greater calorie expenditure. Its unique ability to boost energy, accelerate fat oxidation, and improve body composition makes it a powerful component in any advanced fat loss stack and why at Unmatched® we have chosen paraxanthine as our primary stimulant in pre-workouts like BH2K™ and Outlier.
Fucoxanthin – The Brown Fat Activator
Fucoxanthin, a carotenoid derived from brown seaweed, has been shown to offer unique fat loss benefits through its ability to activate thermogenesis and enhance metabolic rate. It works primarily by up-regulating uncoupling protein 1 (UCP1) in white adipose tissue (stored fat), essentially converting energy-storing fatty acids into energy-burning fat, similar to brown fat activity, which is much more metabolically active due to the presence or more mitochondria (the energy powerhouse of the cell). This mechanism can promote increased calorie expenditure even at rest. Fucoxanthin has also been shown to reduce visceral fat, the fat that can accumulate around organs, making it particularly valuable for improving metabolic health and reducing the risk of all-cause mortality. Unlike traditional stimulants, it works steadily, which makes it an ideal addition to stimulant-free or stimulant based fat loss formulas.
InnoSlim® – AMPK & Nutrient Partitioning
InnoSlim® is a patented blend of Astragalus membranaceus and Panax notoginseng that effectively targets fat loss through a multifaceted metabolic approach. One of its key mechanisms is the up-regulation of adiponectin and activation of AMPK (adenosine monophosphate-activated protein kinase), which is often referred to as the “metabolic master switch” due to its role in cellular energy homeostasis. This activation can promote increased glucose uptake in muscle cells while also reducing glucose absorption into fat cells, leading to improved insulin sensitivity and reduced fat gain. InnoSlim® can also help appetite control and support optimal blood sugar levels, making it a powerful non-stimulant ingredient for sustainable weight management and body recomposition.
Acetyl L-Carnitine (ALCAR) – Brain & Fat Fuel
Seen in products like Unmatched® Electrashred, Acetyl L-Carnitine (ALCAR) plays a vital role in fatty acid metabolism through the transport of long-chain fatty acids into the mitochondria, where they are then oxidized for energy usage. This makes ALCAR particularly effective for enhancing fat utilization during exercise and supporting overall energy production. In this acetylated form, ALCAR also can cross the blood-brain barrier efficiently, offering additional cognitive benefits such as improved focus and mental clarity, which are key factors during calorie deficits or intense training. As part of any fat loss stack, ALCAR can effectively help maximize fat loss while preserving lean muscle and supporting mood and motivation.
KSM-66® Ashwagandha – The Cortisol Controller
KSM-66® Ashwagandha is often known for its powerful adaptogenic properties, but it also plays a key supporting role in fat loss. Through an indirect role of reducing cortisol levels, your body's primary stress hormone, KSM-66® can help counteract stress-induced fat storage, especially around the midsection (where visceral fat is housed). Lower levels of cortisol can also improve sleep quality and support better hormone balance, which are both critical for maintaining an optimally functioning metabolism. Additionally, some studies have shown that KSM-66® may improve strength and endurance, indirectly promoting more effective training and higher daily energy expenditure, which further contributes to fat loss goals. As one of the most clinically studied ayurvedic compounds, KSM-66® is a beneficial powerhouse when it comes to fat loss, cortisol control, and exercise performance.
Chromax® – Blood Sugar Stabilizer
Another unique part of our Electrashred formula is the inclusion of Chromax®. As a clinically studied form of chromium picolinate, Chromax® has been shown to effectively play a key role in supporting healthy blood sugar levels and insulin sensitivity. By improving how the body utilizes insulin, Chromax® can help an individual control appetite and reduce cravings for suboptimal food sources, which can contribute to weight gain. When these factors are controlled in conjunction with a sound nutrition plan and regular exercise, positive improvements in body composition can happen, leading to better fat loss and reduced risk of metabolic disorders.
Final Formulator Thoughts
While fat-burning ingredients like Sinetrol®, MitoBurn®, DNF-10®, Fucoxanthin, and others offer powerful support for metabolism, appetite control, and energy expenditure, it’s important to remember they aren’t a magic bullet, or the end all be all for long-term fat loss. These compounds can greatly enhance and expedite your results when paired with proper nutrition, consistent exercise, controlled stress, and quality sleep—but they won’t overpower poor lifestyle choices. Long-term fat loss is only built on sustainable healthy habits and yes, sometimes sacrifice. Supplements should always be seen as strategic tools that amplify your hard work, not replace it. As stated above, when used purposefully, they can help accelerate progress and optimize your fat loss journey, but real transformation always starts with commitment and consistency.
At Unmatched® we pride ourselves on only putting together the best of the best products that your money can buy and that your body and health will be thankful for. Innovation is in our blood, so we leave no stone unturned to bring you supplements that are effective and deliver results. When it comes to the fat-burner category we wanted to create a unique system that supports fat loss and muscle preservation around the clock. One that hits every facet that is involved with fat burning with a multi-pronged approach. One that can also be combined with other highly effective products and ingredients in our supplement lineup. With this in mind, 2 SHRED was born. 2 SHRED isn’t just a “fat burner”—it’s a weight management system designed to conquer the physiological demands of fat loss:
- Thermogenesis: Sinetrol®, CaloriBurn®, Fucoxanthin
- Appetite Control: DNF-10®, Chromax®, InnoSlim®
- Energy & Motivation: Paraxanthine, ALCAR
- Cortisol Control: KSM-66® Ashwagandha
- Muscle Preservation & Fat Oxidation: MitoBurn®, Forskolin
- Mitochondrial Support: ALCAR, InnoSlim®
In this innovative 2 SHRED formula, each ingredient is dosed for synergy—not redundancy. This AM/PM stack is stimulant-free, science-driven, and designed for real-world results. It can be used in conjunction with products like BH2K, which contains paraxanthine, for a fat-burning-focused pre-workout experience. It can also be used alongside products like Electrashred, Longevity EAA, and Dileucine Peptide to support fat burning, hydration, and recovery no matter the time of day. So whether you’re prepping for stage, for summer, or simply wanting to show up as your best self, you need the right tools in your toolbox. At Unmatched® we formulate with your goals in mind first and foremost so you can reach your goals not just faster but healthier too.
