2SHRED AM/PM Fat Burner Full Product Write Up

AM Blend

MitoBurn® (L-β-Aminoisobutyric Acid)
In recent studies, MitoBurn® (L-BAIBA), a metabolite of L-valine, can stimulate certain “exercise factors” that are released from skeletal muscle in response to muscular stress, in particular muscle contraction. L-BAIBA, a powerful myokine, plays a role in the benefits of regular exercise and begins a positive sequence of events, some of which include increased fatty acid oxidation, improved glucose uptake, and reduced fat mass. Although L-BAIBA primarily works to initiate the “browning” of adipose tissue, it also has been shown to decrease the “beiging” of adipose tissue. This beiging process is when the body reverses the preferred adipose tissue color of brown (high energy usage) back to white (high energy storage). Although most studies have been completed in rats, some results have been obtained in cell culture models and human cohorts and shown a novel function to support L-BAIBA’s involvement in regulation of carbohydrate and lipid metabolism. These studies also support the idea that L-BAIBA primarily exhibits its benefits in conjunction with physical activity. This is shown from skeletal muscle myokines (peptides) that play an important role in the processes listed above. These myokines are produced, expressed, and released by muscle fibers when under forceable contractions and exert both local and pleiotropic effects. Myokines also help to configure the immune-metabolic factor interactions and health promoting effects of physical exercise that stimulate the communication between skeletal muscle and adipose tissue. Adipose tissue itself will release proinflammatory cytokines in response to inactivity and can be a leading reason for the development of metabolic diseases.

This supported research of MitoBurn® (L-BAIBA) and its benefits show that through its myokine activity and communication through physical activity as well as its ability to aid in the browning of adipose tissue, lead it to be a proposed beneficial intervention for the purposes of body composition improvements.

Sinetrol® Xpur (Citrus sinensis Extract, Blood Orange Concentrate)
Metabolism involves the chemical reactions that break down the foods we eat into separate compounds. Sugars, fats, and amino acids provide our body with energy to function daily. These compounds can help our body carry out many functions but when overconsumed they get stored as energy in specific adipose (fat) cells. These cells make up our fatty tissue and can further be classified as white adipose tissue (WAT) and brown adipose tissue (BAT). The color of brown fat is due to a larger number of mitochondria being present in those tissues. Mitochondria are the energy producing structures of cells. Most of our body’s fat is WAT, which stores energy, and when too much WAT builds up the outcome is obesity. This can also be characterized as an enlargement in adipocyte size that results from increased triglyceride storage. Brown adipose tissue, or BAT, on the other hand breaks down blood sugar (glucose) and fat molecules into usable forms of energy, mainly to create heat and maintain body temperature (homeostasis). The ratio between these two adipose tissue types determines the level of energy expenditure, which is unbalanced in those who have more body fat. Research has been centered around finding optimal ways to tap into BAT’s ability to improve obesity, and other metabolic issues.

Sinetrol® is a unique blend of citrus polyphenols that are specifically meant to target body fat mass and improve long term body composition. These citrus polyphenols have been shown to enhance the physiological energetic pathways that influence lipolysis, destoring fat that has been accumulated within white adipose cells. This process occurs at the adipocyte level, helping to reach a balance between energy storage and usage, through a process of browning of adipocytes. Sinetrol® enhances the body’s physiological lipolysis process through phosphodiesterase (PDE) inhibition. This inhibition causes the rate of cyclic adenosine monophosphate (cAMP) to be maintained at sufficient levels, which is needed to enhance the baseline lipolysis yield. This process does two things. First, it can increase lipase activity, which is essential for breaking off fatty acids from triglycerides. Second, it can stimulate an increase in the number of mitochondria in your adipose tissue (mitochondrial myogenesis), thus giving your adipose tissue a brown color in appearance. In addition to this browning process, a protein called UPC-1 (uncoupling protein) is also increased. Studies have shown that it is through these primary mechanisms of action that Sinetrol® exhibits the benefit of enhancing lipolytic rate and browning of adipocytes, leading to increased thermogenesis and utilization of fatty acids and sugars as usable forms of energy.

Coleus forskohlii Extract (20% Forskolin) (root)
Coleus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, Coleus forskholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.

A recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of Coleus forskholii, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass. Coleus forskholii – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy. In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – the perfect scenario in a product such as DTP!

DNF-10® Yeast Hydrolysate (from Saccharomyces cerevisiae)
DNF-10®, a unique peptide derived from yeast (Saccharomyces cerevisiae), is a weight management ingredient that is known for its potential to reduce appetite and support fat loss. DNF-10® works by targeting key hormones and pathways involved in hunger regulation and fat metabolism, offering a natural and sustainable approach to managing body weight and aiding in fat loss.

One of the primary benefits of DNF-10® is its ability to reduce appetite by influencing the levels of ghrelin, known as the "hunger hormone", which plays a crucial role in signaling hunger to the brain, prompting food intake. DNF-10® has been shown to decrease ghrelin levels, which can help reduce feelings of hunger and promote a sense of satiety (state of feeling full). This appetite-suppressing effect can make it more manageable for individuals to adhere to a calorie-deficit, which is essential for fat loss.
In addition to its appetite-suppressing properties, DNF-10® also has been shown to support fat loss by enhancing the body’s ability to break down and utilize stored fat. Research suggests that DNF-10® can increase the activity of enzymes involved in lipolysis, or the breakdown of fatty acids and glycerol so they can then be used as energy. This not only can help reduce fat stores within the body but can also provide a stable source of energy during periods of calorie restriction. This is crucial as it can help an individual maintain physical performance and prevent the typical energy decline often associated with dieting.

DNF-10® also has shown the potential to improve body composition by reducing fat mass while preserving lean muscle. Maintaining muscle mass during a period of weight loss is crucial, as muscle tissue is metabolically active and helps sustain a higher metabolic rate. By supporting fat loss without compromising muscle, DNF-10® can help individuals ensure that important muscle tissue is not broken down for energy and that the targeted tissue being utilized is coming mostly from body fat.

DNF-10® is also backed by clinical research, which has demonstrated its effectiveness in reducing body weight and fat mass in humans. In these studies, participants who supplemented with DNF-10® experienced significant reductions in body weight, waist circumference, and body fat percentage compared to those who didn’t. These studies also showed that daily caloric intake can be decreased by upwards of up to 600 kcal/day, which can equate to roughly 1lb of fat loss per week. These results are promising in the potential of DNF-10® as a safe and effective tool for weight management, particularly when combined with a balanced diet and regular exercise.

InnoSlim® (Astragalus membranaceous and Panax notoginseng Root Extracts)
InnoSlim® is a cutting-edge blend of natural plant extracts, primarily derived from Panax notoginseng and Astragalus membranaceus, that has shown potential to support appetite control and fat loss. InnoSlim® is designed to target key metabolic pathways involved in energy regulation, glucose metabolism, and fat storage, making it a valuable addition to any weight management regimen.

One of the key benefits of InnoSlim® is its ability to regulate glucose metabolism, which plays a crucial role in appetite control and overall fat loss. By activating AMP-activated protein kinase (AMPK), a key enzyme that helps regulate energy balance in the body, InnoSlim® can promote the uptake of glucose into muscle cells, where it can be used for energy rather than being stored as fat. This is not only essential for reducing fat accumulation but also for stabilizing blood glucose levels, which can mitigate cravings resulting in a reduction in total caloric intake.

In addition to its effects on glucose metabolism, InnoSlim® can also support fat loss by impacting a hormone secreted by fat cells called adiponectin. Adiponectin has been identified as a key regulator of insulin sensitivity and inflammation in the human body as well as can also reduce the buildup of triglycerides in skeletal muscle tissue. Adiponectin isn’t a bad thing and at healthy body fat levels its secretion is ok. But, as body fat levels rise, adiponectin secretion tends to decline. This drop in secretion can make it very difficult to lose body fat and can further lead to accumulation of body fat and disease. Where InnoSlim® shines here is that it has been shown to increase adiponectin secretion from fat cells by upwards of 103% as well as reduce inflammatory biomarkers that can impair normal adiponectin secretion. This increased secretion has been shown in studies to result in greater glucose utilization in the skeletal muscle as well as increase fatty acid breakdown in the muscle cells and liver. This mechanism, combined with its ability to enhance fat burning through increased AMPK activation, makes InnoSlim® a powerful tool for reducing body fat and improving body composition.

Regarding appetite, InnoSlim® has shown potential to suppress appetite by influencing hormones and neurotransmitters involved in hunger regulation. Research suggests that InnoSlim® can help modulate the levels of ghrelin, the "hunger hormone," as well as leptin, a hormone that signals satiety to the brain. By balancing these hormones, InnoSlim® can help reduce feelings of hunger and increase the feeling of fullness after meals, making it less of a burden to adhere to a calorie-controlled diet and reduce overall food intake.

Additionally, InnoSlim® is formulated to be a safe and natural supplement, with its ingredients sourced from traditional herbal remedies that have been used for centuries in various cultures. This makes it a suitable option for individuals looking for a natural way to support their weight loss goals without relying on harsh stimulants or synthetic compounds. The blend’s dual-action approach—enhancing fat metabolism while reducing appetite—provides a comprehensive solution for those aiming to achieve sustainable fat loss and improved metabolic health.

Gamma-Butyrobetaine Hydrochloride (GBB)
GBB is a naturally occurring molecule in the body that aids in the boosting of the non-essential amino acid L-carnitine. L-carnitine plays a key role in energy production by its ability to transport fatty acids into the cell’s mitochondria (‘energy producing powerhouse’) to be used for energy. Studies have shown that when GBB is present it can increase the body’s L-carnitine supply, thus providing enhanced benefits. So, in simplified terms, GBB increases usable L-carnitine in the body which increases the mitochondria’s ability to use fatty acids for energy. With the goal of reducing body fat or even improving performance, L-carnitine shows benefits in this field. A study conducted on mammals looked at the responses of L-carnitine supplementation on growth performance as well as circumference measurements. The results showed that weights of muscle tissue increased, whereas abdominal fat percentage decreased. Additionally, GBB has been shown to promote thermogenesis, or the process of heat production in the body, which can further increase calorie expenditure and accelerate fat loss. This dual action, enhanced fat oxidation and increased thermogenesis, can make GBB a powerful ingredient for those looking to maximize their fat loss efforts.

Fucoxanthin 10% (Laminaria japonica) (seaweed)
Fucoxanthin, a carotenoid found in brown seaweed, has shown potential in aiding in fat-burning through its ability to stimulate thermogenesis, the process by which the body burns calories to produce heat. Fucoxanthin does this by promoting the activity of a protein called uncoupling protein 1 (UCP1) in fat tissue, particularly in white adipose tissue, which is responsible for storing excess fat. This activation can help convert stored fat into usable energy, making it easier to burn excess body fat over time and reduce fat accumulation. Additionally, fucoxanthin has been shown to target visceral fat, which is the deep abdominal fat often linked to metabolic disorders, making it a valuable tool for improving body composition and supporting metabolic health. In addition to these weight loss related benefits, fucoxanthin has also been shown to interact positively with the intestinal flora and is capable of alleviating certain degrees of oxidative stress, which can be a preventative measure for many diseases. With its natural origin and promising fat-burning and inflammation mediating effects, fucoxanthin can offer a unique and sustainable approach to weight loss and overall general health.

aXivite® (Microencapsulated Phenylcapsaicin) 1% (100mg)
Axivite®, a patented form of phenylcapsaicin, is an innovation that is showing benefit as a powerful tool for supporting gut health, appetite control and overall fat loss. Derived from capsaicin, the commonly known compound responsible for the heat in chili peppers, Axivite® has been strategically developed to deliver all the beneficial fat-burning and metabolic-boosting effects of traditional capsaicin without the excessive heat or gastrointestinal discomfort. At a clinical dosage of 100-120mg at a 1% extract these qualities contribute to Axivite’s® potency, making this compound a tolerable option for individuals looking to enhance their fat loss in combination with other weight management strategies.

Thermogenesis, the process by which the body burns calories to produce heat, is undoubtedly one of the primary benefits of Axivite®. Phenylcapsaicin stimulates this heat production by activating transient receptor potential vanilloid 1 (TRPV1) receptors, which in turn triggers the body to burn more calories, even at rest. This increased caloric expenditure can accelerate fat loss, especially when combined with a healthy diet and training regimen. By enhancing the body’s natural ability to burn fat, Axivite® can be a beneficial tool for individuals looking to more efficiently target fatty acid utilization and lose body fat.

In addition to its thermogenic properties, Axivite® also plays a role in appetite regulation. Research suggests that phenylcapsaicin can influence the release of appetite-regulating hormones like ghrelin and leptin, which are critical in controlling hunger and satiety cues from the brain. By helping to reduce hunger signals and prolong feelings of fullness, Axivite® can make it easier to adhere to a calorie-controlled diet, ultimately supporting long-term weight management. This dual-action approach—both burning fat and reducing caloric intake—positions Axivite® as a comprehensive solution for fat loss.
Axivite’s® unique formulation and makeup can also support overall gut health, which plays a key role in overall metabolic function. Capsaicin-based compounds like phenylcapsaicin have been shown to positively influence the gut microbiome by promoting the growth of beneficial bacteria within the digestive tract and stomach. A healthy gut environment is beneficial for better nutrient absorption and more efficient metabolism, both of which contribute to fat loss and improved body composition. These gut-enhancing benefits of Axivite® add another layer of support for individuals looking to optimize their weight loss efforts through improved digestion and metabolic health.
Overall, Axivite® can offer a well-rounded approach to fat loss and appetite control by combining the benefits of thermogenesis, appetite regulation, and gut health. Its ability to increase caloric burn while simultaneously reducing hunger can make it an ideal addition for those seeking a natural and effective way to support their weight loss journey. Whether you’re aiming to shed body fat or maintain a healthy weight, Axivite® can provide a scientifically backed and tolerable solution for sustained fat loss results.

PM Blend

KSM-66® Ashwagandha (Withania somnifera) (root) (std 5% withanolindes)
KSM-66®, a patented and highly concentrated form of Ashwagandha (Withania somnifera), is widely known and utilized for its strong adaptogenic properties, offering benefits like stress relief, improved cognitive function, and enhanced athletic performance. There is also a collection of recent research that also highlights its promising role in fat loss and weight management, primarily through mechanisms involving stress reduction, hormonal balance, and improved metabolic health. Let’s look at each of these mechanisms.

One of the primary ways KSM-66® supports fat loss is through its ability to regulate cortisol levels, a hormone released in response to stress. Through a mechanism of action that involves modulating the activity of hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for the body’s stress response. KSM-66® can help to reduce cortisol production, which can lead to a decrease in stress-related overconsumption of food and prevent the buildup of body fat. Clinical research has shown that KSM-66® usage can reduce cortisol levels by up to 27.9% in chronically stressed adults.

In addition to stress management, KSM-66® has also been shown to enhance metabolic health by improving overall thyroid function, which plays a key role in metabolic regulation. Imbalances in thyroid hormones can often lead to weight gain and difficulty in losing fat. Studies suggest that KSM-66® can help normalize levels of thyroid hormones (T3 and T4), leading to a more efficient metabolism, which can help the body burn calories more effectively, promoting fat loss and preventing fat gain.

KSM-66® is also linked to improved body composition in users. Clinical studies involving individuals who were engaged in resistance training as well as supplementing with KSM-66® resulted in greater reductions in body fat percentage compared to placebo groups as well as enhancements in muscle mass, strength and endurance. Since muscle mass increases the body's resting metabolic rate, KSM-66® can boost overall caloric expenditure, even at rest, which in turn can contribute to overall fat loss. This dual effect of building lean muscle while reducing fat can make KSM-66® particularly effective for improving body composition.

In addition to its appetite-suppressing properties, DNF-10® also has been shown to support fat loss by enhancing the body’s ability to break down and utilize stored fat. Research suggests that DNF-10® can increase the activity of enzymes involved in lipolysis, or the breakdown of fatty acids and glycerol so they can then be used as energy. This not only can help reduce fat stores within the body but can also provide a stable source of energy during periods of calorie restriction. This is crucial as it can help an individual maintain physical performance and prevent the typical energy decline often associated with dieting.

L-Theanine
L-Theanine, an amino acid commonly found in the leaves or various types of tea, is most notably known for its benefits towards stress management, mental clarity and alertness, and improvements in sleep. While there are several studies on animals that show L-Theanines ability to improve insulin sensitivity and glucose tolerance, most of L-Theanines fat loss benefits in humans lie in its ability to indirectly influence fat loss through the benefits listed above.

L-Theanine can promote a sense of relaxation through its ability to increase the production of hormones like GABA, serotonin, and dopamine. This reduction in stress levels can balance circulating cortisol (stress hormone) in our bodies. High levels of cortisol are often associated with increased cravings, overconsumption of high calorie and low satiating foods, which can lead to an accumulation in fat storage.

Regarding improvements in sleep, poor sleep quality and duration are also often linked to weight gain and/or difficulty losing fat. L-Theanine can help promote a deeper, more restful sleep through its ability to calm the mind and enhance alpha brain wave activity, which are most common right before you drift off to sleep. These more optimal sleep characteristics can support enhanced metabolic health, reduce cravings, and regulate our hormones leptin and ghrelin, which manage appetite and satiety.

So, as you can see, L-Theanine doesn’t directly impact fat loss like other traditional fat loss ingredients. It does however have a synergistic effect and works indirectly to improve other aspects of daily life that do have a large impact on weight management.

Saffron Extract (Crocus sativus) (stigmas) (SaffSerene™)
SaffSerene™, a standardized extract of saffron (Crocus sativus), is a unique addition that can offer promising benefits for fat loss, primarily through its ability to regulate appetite and reduce emotional eating. Saffron has been shown to increase the levels of serotonin, a neurotransmitter that helps control mood and cravings. By promoting a balanced mood and reducing the urge for overconsumption, SaffSerene™ can help curb excessive calorie intake, making it easier to adhere to a fat loss diet. Additionally, saffron extract may enhance satiety, helping users feel fuller for longer and reducing overall food consumption. These appetite-suppressing effects, combined with its mood-enhancing properties, make SaffSerene™ a valuable supplement for supporting fat loss efforts, especially for those struggling with emotional eating.

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InnoSlim® Overview

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2SHRED AM/PM Fat Burner Full Product Write Up

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