Cognishot

CogniShot is the perfect supplement to have on hand when brain energy, reactive time, focus, memory recall, learning and mental clarity is needed. Read below to see how our naturally sweetened, clinically dosed and convenient liquid shot can help your brain perform at this highest level while staying protected.

Sodium (as Sodium Citrate) – 100 mg

Sodium is foundational to neuronal excitability and cognitive processing speed. Every thought, reaction, and memory recall event is dependent on voltage-gated sodium channels initiating depolarization across neuronal membranes. Without proper extracellular sodium concentration, action potentials cannot fire efficiently, leading to slower signal propagation and reduced cognitive sharpness.

In addition to its role in synaptic transmission, sodium also influences cerebral blood flow through its effects on plasma volume and vascular tone. During periods of intense mental work, mild dehydration or electrolyte shifts can impair attention and reaction time. By providing sodium in citrate form — which is well absorbed and less harsh on the GI tract — CogniShot supports rapid neural firing, improved signal fidelity, and sustained mental endurance under stress.

Potassium (as Potassium Citrate) – 150 mg

Potassium is the dominant intracellular electrolyte and is critical for restoring resting membrane potential following neuronal depolarization. After sodium influx triggers a signal, potassium efflux is responsible for repolarizing the neuron, preparing it for the next transmission. This process directly impacts cognitive stamina and the brain’s ability to sustain rapid-fire signaling.

Suboptimal potassium levels can contribute to mental fatigue, reduced alertness, and impaired synaptic efficiency. Adequate potassium ensures proper electrochemical cycling, which is essential for working memory, executive function, and processing speed. In high-performance cognitive settings, maintaining optimal potassium gradients enhances neural recovery between signals and supports consistent mental output.

Magnesium (as Magnesium Citrate) – 75 mg

Magnesium is one of the most neurologically important minerals in the human body. It regulates NMDA receptor activity by acting as a voltage-dependent gatekeeper, preventing excessive calcium influx and excitotoxicity. This modulation protects neurons while maintaining efficient excitatory transmission — a delicate balance required for learning and memory consolidation.

Magnesium also plays a central role in ATP stabilization. In fact, biologically active ATP exists as Mg-ATP. Without adequate magnesium, mitochondrial energy production becomes less efficient, which directly impacts cognitive stamina. Furthermore, magnesium supports GABAergic signaling, contributing to calm focus rather than overstimulation. This makes it particularly valuable in a ketone-driven formula where enhanced energy metabolism is paired with neurological stability.

goBHB® (D- and L-β-Hydroxybutyrate Free Acid) – 3,000 mg Total

β-Hydroxybutyrate is not simply an alternative fuel, it’s a metabolic signaling molecule with extremely beneficial neurocognitive implications. The brain consumes approximately 20% of total resting energy expenditure, and ketones provide a highly efficient substrate for mitochondrial ATP production. BHB bypasses glycolysis and directly feeds into the Krebs cycle as acetyl-CoA, enhancing mitochondrial efficiency and reducing reactive oxygen species production relative to glucose metabolism.

Importantly, BHB functions as a histone deacetylase (HDAC) inhibitor, influencing gene transcription associated with oxidative stress resistance, synaptic plasticity, and neuronal resilience. It has also been shown to suppress NLRP3 inflammasome activation, reducing neuroinflammatory signaling that can impair cognitive performance.

Acute exogenous ketone supplementation has demonstrated improvements in executive function, working memory, and mental clarity in emerging research. The inclusion of both D- and L- free acid forms may allow for rapid elevation of circulating ketones while potentially extending metabolic signaling effects. In CogniShot, goBHB® provides immediate cerebral energy while simultaneously supporting long-term neuroprotective pathways.

Lion’s Mane (Hericium erinaceus) Fruiting Body – 500 mg

Lion’s Mane contains bioactive diterpenoids (erinacines) and aromatic compounds (hericenones) that stimulate nerve growth factor (NGF) production. NGF is essential for the maintenance and survival of basal forebrain cholinergic neurons, which are the same neuronal populations critical for memory encoding and attention regulation.

In human trials, Lion’s Mane supplementation has been associated with improvements in mild cognitive impairment and enhanced cognitive function scores over time. Mechanistically, increased NGF supports dendritic branching, synaptic formation, and neuronal repair. These effects contribute to improved neural plasticity — the biological foundation of learning and memory.

Additionally, Lion’s Mane may support mood balance and stress resilience, indirectly enhancing executive function and focus. In CogniShot, it serves as the structural and regenerative complement to the formula’s acute energy and neurotransmitter support.

Cognizin® Citicoline – 250 mg

Citicoline (CDP-choline) is a pivotal compound in brain metabolism, acting as both a choline donor and a cytidine source. Once ingested, it is metabolized into choline and cytidine, which then cross the blood-brain barrier and are reassembled into CDP-choline within neuronal tissue.

The choline component supports acetylcholine synthesis, directly enhancing attention, learning capacity, and information processing. Acetylcholine is the primary neurotransmitter involved in memory formation and cortical activation. Increased availability can enhance focus, mental clarity, and cognitive drive.

The cytidine component contributes to phosphatidylcholine synthesis, improving neuronal membrane integrity and facilitating synaptic signaling efficiency. Clinical studies on Cognizin® demonstrate improvements in focus, attention, psychomotor speed, working memory, and frontal lobe bioenergetics. This dual mechanism makes it one of the most comprehensive cognitive support compounds available.

CognatiQ® (Coffea robusta) (Whole Coffee Fruit Extract) – 100 mg

CognatiQ® is a standardized whole coffee fruit extract shown in human clinical trials to significantly elevate circulating brain-derived neurotrophic factor (BDNF) levels. BDNF plays a central role in synaptic plasticity, neuronal survival, and memory consolidation. Higher BDNF levels correlate with improved learning efficiency and cognitive adaptability.

Unlike caffeine, which primarily works through adenosine receptor antagonism, coffee fruit extract appears to modulate neurotrophic signaling pathways, supporting both acute and long-term brain health. Increased BDNF enhances dendritic spine formation and strengthens synaptic connectivity, which can improve processing speed and cognitive flexibility.

When combined with Lion’s Mane, which stimulates NGF, CognatiQ® creates a dual-neurotrophic environment supporting both immediate cognitive activation and long-term neural resilience.

 

REFERENCES

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