Collagen Peptide-6

A truly next-generation multi-type collagen blend, Collagen Peptide 6 combines the structural power of diverse collagen sources with targeted cofactors and advanced bioactives for complete longevity and beauty support. Featuring hydrolyzed bovine collagen peptides and PureMarine collagen peptides for Types I–IV collagen, plus eggshell membrane collagen to deliver rare Types V and X, this unique blend provides the support to rebuild the foundation of skin, joints, bones, and connective tissue. To amplify these effects, we have included PureWay-C®, a highly bioavailable form of vitamin C essential for collagen synthesis, D-Biotin to reinforce keratin-based tissues like hair and nails, and hyaluronic acid to support deep hydration and elasticity. We have also included Peptzyme AG® (protease blend), which strategically can enhance collagen utilization by reducing inflammatory byproducts. Finally, MitoPrime® (L-ergothioneine) provides cellular antioxidant protection, protecting vital collagen fibers from oxidative and glycation damage, which can cause stiff, brittle, and less functional tissues over time. Together, these synergistic ingredients create a comprehensive collagen system that supports youthful skin, resilient joints, stronger bones, and total connective tissue health. We aren’t just rebuilding collagen, but we are preserving it for the long term.

Vitamin C (as Liposomal PureWay C®)

Vitamin C is one of the most essential nutrients for collagen health, and when delivered in advanced forms like Liposomal PureWay-C®, it can provide significantly enhanced absorption, retention, and cellular uptake compared to standard ascorbic acid. Research has shown that PureWay-C® is absorbed more efficiently and retained longer in human plasma than other forms of vitamin C, including calcium ascorbate and ascorbic acid, resulting in superior antioxidant protection and immune benefits. Its lipid metabolites and liposomal delivery also improve tolerability, reducing the gastrointestinal discomfort that can be sometimes seen with high doses of conventional vitamin C.

When it comes to a multi-type collagen blend like Collagen Peptide 6, PureWay-C® plays a crucial and foundational role. Collagen synthesis requires vitamin C as a cofactor for prolyl and lysyl hydroxylase enzymes, which stabilize and cross-link the triple-helix collagen structure. Without adequate vitamin C, collagen production is impaired, leading to weaker connective tissue, slower recovery, and reduced skin elasticity. Studies have consistently demonstrated that sufficient vitamin C intake enhances the body’s ability to incorporate amino acids from collagen peptides into strong, functional collagen.

Beyond synthesis, vitamin C also amplifies the beauty and joint health benefits often associated with collagen. In a placebo-controlled trial, oral vitamin C supplementation improved skin hydration, elasticity, and overall dermal health by promoting collagen production and reducing oxidative damage. PureWay-C®, specifically, has been shown to provide stronger protection against oxidative stress and inflammatory markers than traditional vitamin C, making it an ideal partner to multi-type collagen for supporting both skin vitality and connective tissue resilience. For athletes and active individuals, this synergy translates into stronger tendons and ligaments, quicker recovery, long-term joint health, and protection against degradation.

Biotin (as d-biotin)

D-Biotin, also known as vitamin B7, is an essential water-soluble vitamin that plays a central role in energy metabolism as well as keratin production. As a coenzyme for carboxylases, biotin is directly involved in the metabolism of fatty acids, amino acids, and glucose, which are pathways that impact skin cell turnover, hair follicle strength, and nail growth. Unlike collagen, which provides structural proteins, D-Biotin enhances the body’s ability to generate keratin, the primary protein that makes up hair, nails, and the outer layer of skin.

Clinical studies have consistently demonstrated the cosmetic benefits of biotin supplementation. In individuals with brittle nail syndrome, 2.5 mg/day of biotin for 6 months increased nail thickness by 25% and reduced splitting and brittleness. Another trial found that biotin supplementation improved nail firmness and reduced splitting in 63% of participants. Similarly, while biotin deficiency is rare, suboptimal levels are associated with thinning hair, seborrheic dermatitis, and brittle nails, which are issues that supplementation has been shown to improve.

Its inclusion in this multi-type collagen blend provides a complementary role by addressing tissues that collagen alone cannot optimize. Collagen peptides (Types I, II, III, IV, V, X, etc.) rebuild and strengthen the dermal matrix, joints, and connective tissue, while D-Biotin enhances keratin infrastructure in hair, skin, and nails. This combination creates a “dual-pathway” approach: collagen supports deep structural integrity, while biotin improves the outer layer’s resilience and appearance.

For longevity-focused blends like Collagen Peptide 6, this pairing is exceptionally powerful. As collagen density naturally declines with age, nails and hair also become weaker and more brittle. By adding D-Biotin, this formula not only helps restore collagen-dependent tissues but also ensures that keratin-based structures remain strong and healthy. Together, they address both the scaffolding (collagen) and the surface (keratin) of the body, supporting a more youthful appearance and functional tissue resilience.

Hydrolyzed Bovine Collagen Peptides

We begin our collagen matrix with premium hydrolyzed bovine collagen peptides, primarily rich in Type I and Type III collagen. These highly bioavailable protein fragments directly support skin, joint, bone, and connective tissue health. After ingestion, collagen peptides are absorbed as di- and tripeptides, where they act as both building blocks and bioactive signals to stimulate fibroblasts, chondrocytes, and osteoblasts. Clinical research has shown that daily supplementation with bovine collagen peptides can significantly improve skin elasticity, hydration, and dermal density. One randomized, placebo-controlled trial in 69 women found that 2.5 g/day of collagen peptides for 8 weeks improved skin elasticity by up to 7% compared to placebo. Another study demonstrated that oral collagen peptides increased dermal collagen density by 6% after just 4 weeks, with continued benefits over 12 weeks.

Beyond skin health, bovine collagen peptides also play a major role in joint and bone health, which has a large influence on overall longevity and health span. A 24-week double-blind, placebo-controlled study in athletes with activity-related joint pain found that 10 g/day of collagen peptides significantly reduced joint discomfort compared to placebo. In another trial, postmenopausal women taking 5 g/day of bovine collagen peptides for 12 months experienced increased bone mineral density (BMD) in the spine and femoral neck by 3%, alongside favorable changes in bone formation markers. These outcomes highlight collagen’s ability to reinforce musculoskeletal resilience, which is a cornerstone of healthy aging.

As the foundational collagen source in Collagen Peptide 6, bovine collagen peptides (Types I and III) reinforce skin, tendons, ligaments, vasculature, and bone, while complementing other collagen types (e.g., Type IV from marine sources and Type V and X from eggshell for connective tissue and bone matrix support). By combining multiple sources, a strategically crafted blend addresses the full spectrum of tissues that decline with age—skin elasticity, joint mobility, bone strength, and connective tissue integrity.

Also, when paired with other supportive nutrients like vitamin C (as PureWay-C®) to drive collagen synthesis, and longevity enhancers like hyaluronic acid and d-biotin, bovine collagen peptides act as the perfect base for a comprehensive healthy-aging matrix. The synergy of all of these ingredients not only replenishes collagen lost with age but also helps protect against age-related decline in joint function, bone density, and skin structure—extending beyond cosmetics and into true functional longevity.

Pure Marine® Collagen Peptides

PureMarine® collagen peptides are a unique inclusion derived from wild-caught marine sources. Naturally providing a spectrum of collagen types, Type I, II, III, and IV, this matrix is a unique blend compared to others. While Types I, II, and III collagen deliver support and focus on skin, joints, and other connective tissues, Type IV adds support for skin barrier function, circulation, and organ integrity. What this means is that even the basement membranes, which are vital for skin smoothness, vascular health, and kidney function are protected, which are areas that decline with aging. Marine collagen is also known for its smaller peptide size, which translates into superior absorption and bioavailability. Studies have shown that marine collagen peptides are absorbed more efficiently than bovine or porcine collagen, leading to higher circulating levels of hydroxyproline-containing peptides that stimulate fibroblast activity and collagen synthesis.

Clinical studies demonstrate significant benefits for skin health. A double-blind, placebo-controlled trial found that oral supplementation with 10 g/day of marine collagen peptides for 12 weeks improved skin hydration by 12%, elasticity by 8%, and reduced wrinkle depth by 13% compared to placebo. Another study in middle-aged women showed that 5 g/day of marine collagen for 8 weeks significantly increased skin elasticity and dermal density, confirming its role in anti-aging and skin structural support.

Going beyond skin, marine collagen peptides also provide targeted joint and connective tissue support due to their Type II and Type IV content. A 6-month intervention in subjects with knee discomfort found that daily marine collagen peptide intake reduced joint stiffness and improved mobility scores by over 20% compared to baseline.

In Collagen Peptide 6, PureMarine® collagen peptides provide a broad-spectrum foundation by covering Types I–IV in a single source (Type IV is rarely seen in most blends). This complements the hydrolyzed bovine collagen mentioned above (rich in Types I and III for bone and connective tissue), and the eggshell membrane we will discuss next, creating a complete matrix that mirrors the diversity of human collagen distribution. By including PureMarine® we not only boost bioavailability but also ensure coverage of underrepresented collagen types—especially Type IV, critical for maintaining vascular and organ health with aging.

Eggshell Membrane Collagen

Lastly in our collagen matrix we have eggshell membrane collagen, which are a naturally occurring source of Types V, and X collagen, as well as bioactive compounds like glycosaminoglycans (GAGs), hyaluronic acid, and chondroitin sulfate. This composition makes them especially valuable for joint, tendon, and connective tissue health, which as mentioned above, are areas that deteriorate with age. Unlike many single-source collagens, eggshell membrane provides not just structural proteins but also the ancillary molecules that lubricate joints and cushion connective tissue.

Clinical evidence supports their role in joint function and mobility. In a randomized, double-blind, placebo-controlled study, supplementation with 500 mg/day of natural eggshell membrane significantly reduced joint pain and stiffness in as little as 7 days, with continued improvements at 30 and 60 days. Another trial found that daily supplementation improved flexibility by 26% and reduced stiffness by 28% over 60 days compared to placebo. These outcomes are particularly meaningful for aging populations, where mobility and connective tissue resilience directly influence quality of life and longevity.

Eggshell membrane collagen also contributes to skin health due to their hyaluronic acid content. A clinical trial in healthy women showed that daily supplementation for 8 weeks increased skin elasticity by 25% and reduced wrinkle depth by 16% compared to baseline. This dual benefit—joint and skin—positions eggshell membrane collagen as a versatile ingredient in both performance and longevity formulas.

In Collagen Peptide 6, eggshell membrane collagen fills critical gaps by delivering Type V and Type X collagens, which are less abundant in bovine or marine sources but are essential for connective tissue scaffolding and bone matrix development. Type V regulates the assembly of collagen fibrils, ensuring proper organization of Type I and III fibers, while Type X supports cartilage mineralization and bone health. By pairing eggshell membrane with bovine (Types I & III) and marine (Types I–IV) collagens, the overall blend becomes a comprehensive matrix that addresses nearly every collagen type relevant to healthy aging.

This broad-spectrum approach found in this formula is ideal for sound cosmetic support as well as supporting optimal longevity.

Hyaluronic Acid (as sodium hyaluronate)

As mentioned above, hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found in high concentrations within the skin, eyes, and joints, where it plays a critical role in hydration, lubrication, and tissue resilience. Its unique ability to bind up to 1,000 times its weight in water makes it one of the body’s most powerful natural moisturizers. However, HA levels decline with age, contributing to skin dryness, loss of elasticity, and reduced joint cushioning.

Clinical trials confirm its effectiveness in skin health and joint support. A randomized, placebo-controlled trial found that oral supplementation with 120 mg/day of hyaluronic acid for 12 weeks significantly improved skin hydration and reduced wrinkle depth compared to placebo. Another study showed that oral HA at 200 mg/day for 8 weeks increased skin elasticity by 21% and reduced skin roughness by 26%. In terms of joint health, research demonstrates that oral HA improves mobility and reduces pain; one study reported that 80 mg/day for 12 weeks reduced knee discomfort scores by 33% in adults with mild knee osteoarthritis.

In this collagen formula, hyaluronic acid works synergistically with collagen peptides to provide both structural support (collagen) and hydration/lubrication (HA). Collagen peptides rebuild the dermal matrix, ligaments, and cartilage, while HA ensures those tissues are hydrated, elastic, and cushioned. This combination is particularly important for healthy aging, as collagen density and HA levels both decline with age, leading to visible skin aging and compromised joint function.

By pairing multi-source collagen (Types I, II, III, IV, V, X) with hyaluronic acid, we are not only strengthening connective tissue but also helping to restore the water-retaining matrix that keeps skin hydrated and joints flexible. This results in a comprehensive formula that supports beauty-from-within (hydrated, elastic skin) and functional longevity (joint comfort, mobility, resilience)—benefits backed by human clinical studies.

Pepzyme AG®

Pepzyme AG® is a systemic protease enzyme blend, designed to support protein digestion, circulation, and tissue recovery. Unlike collagen peptides, which provide the building blocks for new tissue, Pepzyme AG® supplies the enzymatic activity that helps break down undigested proteins, fibrin, and inflammatory byproducts that can accumulate in the body. This process not only enhances nutrient absorption but also creates a healthier internal environment for collagen peptides to be utilized more effectively.

Clinical research on proteolytic enzyme blends demonstrates significant benefits for inflammation and recovery. In a double-blind, placebo-controlled study on patients with post-traumatic swelling, oral protease enzymes reduced swelling by nearly 50% faster within 3 days compared to placebo. Another trial evaluating protease supplementation for osteoarthritis found that enzyme therapy was as effective as standard NSAID treatment in reducing pain and improving mobility over 6 weeks, but with fewer side effects. Protease blends have also been shown to shorten recovery time from sports injuries by enhancing fibrin breakdown and reducing markers of inflammation, leading to faster return to activity.

Pepzyme AG® works as a bioavailability enhancer and recovery catalyst for Collagen Peptide 6. By pairing collagen peptides (Types I, II, III, IV, V, X) with a protease blend, we are helping to ensure optimal digestion of the peptides, minimize competition with undigested dietary proteins, and reduce systemic inflammation that may hinder collagen deposition.

MitoPrime® (L-Ergothioneine)

MitoPrime®, L-Ergothioneine, is a unique and powerful antioxidant that plays a critical role in protecting cellular health, enhancing mitochondrial function, and increasing overall longevity. One of its key benefits is its ability to reduce oxidative stress by neutralizing harmful free radicals, which are linked to aging and various chronic diseases. Unlike many antioxidants that are rapidly metabolized, MitoPrime® is naturally transported into cells where it can provide long-lasting protection against oxidative damage.

Collagen fibers are highly susceptible to degradation from free radicals, UV radiation, and glycation processes — all of which accelerate wrinkles, loss of elasticity, and joint degeneration. By acting as a cellular antioxidant and mitochondrial protector, MitoPrime® can help reduce oxidative stress that would otherwise damage vital collagen fibers.

In vitro and preclinical data show that ergothioneine can reduce advanced glycation end-products (AGEs) formation, which are known to stiffen and damage collagen crosslinks. By slowing glycation, MitoPrime® helps preserve the strength and flexibility of collagen structures in skin and connective tissue. Ergothioneine has also been shown to modulate inflammatory cytokines and protect fibroblasts — the cells that actively produce collagen — thereby maintaining collagen synthesis capacity under stress conditions.

A unique inclusion in Collagen Peptide 6, MitoPrime® serves as the safeguard of collagen integrity. While Types I, II, III, IV, V, and X collagen peptides provide raw building blocks, MitoPrime® ensures those fibers are protected from oxidative and glycation-related breakdown. This dual approach means consumers don’t just rebuild collagen — they maintain it longer and at higher quality. What this can translate into is fewer wrinkles, improved elasticity, and stronger skin matrix over time. For longevity and joint health, it means slower connective tissue degradation, supporting mobility and resilience with age. By combining MitoPrime® with collagen peptides and other cofactors like vitamin C and hyaluronic acid, Collagen Peptide 6 targets both collagen production and preservation, which is vital for healthy aging and overall health span.

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