Immuno-IGG Full Writeup

When it comes to stimulating muscle protein synthesis, it is common knowledge that resistance training in conjunction with consuming adequate amounts of protein/amino acids (namely leucine) needs to take place. Over the years, the supplement industry has pioneered innovation in the protein powder space through offering unique combinations and types of proteins, from whey, casein, egg, plant based, etc. to tailor to every athlete who wishes to supplement their overall diet with a protein powder. Recently there have also been products being produced with the utilization of bioactive peptides/proteins with an overall goal of not only stimulating muscle protein synthesis but also to provide additional support for various other systems, like the immune, cardiovascular, and digestive systems. Colostrum being a popular option for these products has shown promise in the benefits of immunity, supporting muscle growth, as well as increasing nutrient absorption, but it isn’t colostrum itself that is the star, it’s the immunoglobulins and other growth factors that colostrum contains where the true benefit lies.

Immunoglobulins, also known as antibodies, are proteins that your immune system produces to fight harmful germs, such as viruses and other bacteria. Supplementing with additional immunoglobulins can help strengthen your immune system so you can continue to fight infections and remain healthy. ImmunoLin®, a protein based dietary supplement containing over 50% immunoglobulins, helps support optimal digestive function as well as aids in maintaining a healthy mucosal immune system within the human body. ImmunoLin® exhibits a similar structure to that of breast milk and colostrum, which also contain high amounts of immunoglobulins and other nutritive factors that are vital for the growth and development of a newborn. The primary benefits of ImmunoLin®, being a serum-derived bovine immunoglobulin/protein isolate, are that it may help improve digestive health and nutritional status by lowering immune activation through proposed mechanisms that involve antigen binding and through strengthening the gut barrier function and integrity.

ImmunoLin® exerts its immunomodulatory effects through multiple mechanisms. Key components of ImmunoLin®, such as immunoglobulins, lactoferrin, cytokines, and growth factors, interact with immune cells and mediators to regulate immune responses. Immunoglobulins, including IgG, IgM, and IgA, confer passive immunity by neutralizing pathogens and toxins, thus reducing the risk of infections. Lactoferrin exhibits antimicrobial properties by maintaining certain amounts of iron, which is essential for microbial growth and modulating inflammatory responses. Cytokines and growth factors present in ImmunoLin® contribute to immune cell activation, proliferation, and differentiation, promoting effective immune surveillance and defense mechanisms.

As a concentrated serum-derived bovine immunoglobulin/protein isolate, ImmunoLin® can provide additional support in maintaining healthy muscle tissue and supporting recovery following strenuous training sessions utilizing the high levels of bovine immunoglobulins and other peptides that it contains. Through its rich components of bioactive components, ImmunoLin® exerts multifaceted effects on immune responses, including immune modulation, antimicrobial activity, and anti-inflammatory properties. Extensively studied, clinical research confidently supports the efficacy of ImmunoLin® in bolstering immune defenses, reducing the incidence of infections, and improving overall health outcomes. 

Utay, N. S., Somasunderam, A., Hinkle, J. E., Petschow, B. W., Detzel, C. J., Somsouk, M., Fichtenbaum, C. J., Weaver, E. M., Shaw, A. L., & Asmuth, D. M. (2019). Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART. Pathogens & immunity4(1), 124–146.

Asmuth, D. M., Ma, Z. M., Albanese, A., Sandler, N. G., Devaraj, S., Knight, T. H., Flynn, N. M., Yotter, T., Garcia, J. C., Tsuchida, E., Wu, T. T., Douek, D. C., & Miller, C. J. (2013). Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. AIDS (London, England)27(14), 2207–2217.

Detzel, C. J., Horgan, A., Henderson, A. L., Petschow, B. W., Warner, C. D., Maas, K. J., & Weaver, E. M. (2015). Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PloS one10(4), e0120278.

Petschow, B. W., Burnett, B., Shaw, A. L., Weaver, E. M., & Klein, G. L. (2014). Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy. Clinical and experimental gastroenterology7, 181–190.

Shafran, I., Burgunder, P., Wei, D., Young, H. E., Klein, G., & Burnett, B. P. (2015). Management of inflammatory bowel disease with oral serum-derived bovine immunoglobulin. Therapeutic advances in gastroenterology8(6), 331–339.